Role of oxidative stress and inflammatory cytokines in renal injury

Reza Mohammadrezaei Khorramabadi, Peyman Amanolahi Baharvand, Hasanvad Amin

Abstract


Renal injury caused by oxidative stress and inflammatory cytokines is one of the most important causes of chronic renal disease and renal failure. An increase in the level of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and transforming growth factor-beta (TGF-β), and the reduction of the level of these two oxidative stress indexes, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and enhancing  malondialdehyde (MDA) expression have shown that inflammatory mediator and oxidative stress are responsible for developing nephropathy by raising the invasion of inflammatory cell, hypertrophy with vacuolar  degeneration leading to renal tubular cells apoptosis.




Please cite this paper as: Mohammadrezaei Khorramabadi R, Amanolahi Baharvand P, Hasanvand A. Role of oxidative stress and inflammatory cytokines in renal injury. Journal of Ischemia and Tissue Repair. 2019;3:e07.


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