Opisthorchis viverrini-IgG antibody and proinflammatory cytokines IL-1β and TNF-α polymorphisms; synergy factor analysis

Beuy Joob1*, Viroj Wiwanitkit2

Abstract


Cholangiocarcinoma is an important biliary tract cancer. This cancer is highly prevalent in Indochina.
The opisthorchiasis, the Opisthorchis viverrini infection, is an important etiological factor for
cholangiocarcinogenesis. The measurement of immune response, immunoglobulin G, is a way to monitor
the intensity of infection, which can further imply the risk of cholangiocarcinoma. Regarding the disease
severity, the role of genetic underlying factors including to proinflammatory cytokines polymorphisms,
are mentioned for the important roles. There are some previous case controls studies to assess the odds
ratio of the mentioned factors. Nevertheless, in real situation, there are usually complete multifactorial
effects of several underlying factors. The synergistic effect due to multifactorial underlying etiologies is
very interesting. Here, the authors performed synergy factor analysis for the combined O. viverrini-IgG
antibody and to proinflammatory cytokines polymorphisms (IL-1β and TNF-α).
Keywords: Cholangiocarcinoma, Immunoglobulin, Interleukin, Tumor necrotic factor, Polymorphism,
synergy

Citation: Joob B, Wiwanitkit V. Opisthorchis viverrini-IgG antibody and proinflammatorycytokines IL-1β and TNF-α polymorphisms; synergy factor analysis. Journal of Ischemia and Tissue Repair.2019;3:e03.


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