Effect of molecular change of D68 variants (D168G and D168V) on asunaprevir response in hepatitis C virus 1b infection

Pathum Sookaromdee1*, Viroj Wiwanitkit2

Abstract


Hepatitis C virus (HCV) infection is an important hepatitis virus that can cause chronic liver problem
including to hepatoma. The antiviral drug management for HCV infection is presently recommended,
however, the important problem is the emerging drug resistance. Regarding the new protease inhibitor,
asunaprevir, the resistance is already observed. The genetic variant of HCV is mentioned for its
interrelationship with asunaprevir resistance. Here, the authors analyze the effect of molecular change
of D68 variants (D168G and D168V). The different degree of asunaprevir due to the single amino acid
substitution in the studied variants is observable.
Keywords: Asunaprevir, Hepatitis C virus 1a, Resistance, Antiviral drugs

Citation: Sookaromdee P, Wiwanitkit V. Effect of molecular change of D68 variants(D168G and D168V) on asunaprevir response in hepatitis C virus 1b infection. Journal of Ischemia andTissue Repair. 2019;3:e02.


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