Patatin-like phospholipase domain-containing protein 3 polymorphism and hepatic cell disorder; gene ontology analysis

Beuy Joob1*, Viroj Wiwanitkit2

Abstract


Patatin-like phospholipase domain-containing protein 3 (PNPLA3) is an important molecule that is
mentioned for the pathogenesis of the liver disorders including to hepatocellular carcinoma. The
immunopathogenesis via migration of immune cells is reported in the PNPLA3 variant. Here, the authors
perform a standard gene ontology analysis on the PNPLA3 I148M. Comparing to the naïve molecule,
gene ontology analysis showed no significant difference of biological function of PNPLA3 I148M variant.
This analysis can imply that the actual underlying pathogenesis of PNPLA3 I148M variant related liver
disorder is due to other process rather than the direct functional change.
Keywords: Patatin-like phospholipase domain-containing protein, Ontology, Liver, Immunopathogenesis,
Hepatocellular carcinoma

Citation:Joob B, Wiwanitkit V. Patatin-like phospholipase domain-containing protein 3polymorphism and hepatic cell disorder; gene ontology analysis. Journal of Ischemia and Tissue Repair.2019;3:e05.


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